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Nitric Oxide Basics

By the Melonex Editorial Team. Updated October 2026. Sources linked in the text.

Quick answer: Nitric oxide is a gas made by the lining of your blood vessels. It signals the muscle in vessel walls to relax, which widens them and eases blood flow. Age, smoking, inactivity and high blood sugar reduce it; exercise and vegetables rich in nitrate support it.

What it does

The endothelium, the thin lining inside your arteries, turns arginine into nitric oxide. The gas tells the surrounding muscle to relax, so the vessel widens.

What lowers it

  • Smoking
  • Inactivity
  • High blood sugar and high cholesterol
  • Ageing

What supports it

  • Regular aerobic exercise
  • Leafy greens and beetroot, which provide nitrate
  • Not smoking

Where supplements fit

Arginine and citrulline supply raw material, but in healthy people the body usually has enough. Effects in studies are modest.

General information, not medical advice. Melonex is a dietary supplement and is not intended to diagnose, treat, cure or prevent any disease.

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